一、个人简介

何小凤，博士，副研究员，硕士生导师。2020年博士毕业于中科院昆明植物研究所药物化学专业，2020年~2023年于中科院昆明植物研究所从事博士后研究工作。主要开展中药及民族药功效物质的发现与创新应用研究。代表性研究工作：（1）以活性筛选和LC-MS分析为导向，系统开展了药食两用中药草果和草豆蔻的抗糖尿病活性成分研究，分离鉴定包括黄烷醇-单萜杂合体、二苯基庚烷-查尔酮杂合体、二苯基庚烷-二氢黄酮杂合体等多种结构类型的新化合物150余个，发现70余个靶向PTP1B和α-葡萄糖苷酶且活性显著优于阳性药物的活性化合物，为扩大两种药食同源中药的应用以及新型降血糖先导分子的发现提供了重要的化学和药理学依据。（2）以抗肝癌活性为导向，结合LC-MS分析，从蒿属中药南牡蒿活性部位中分离鉴定9种新颖骨架类型的45个新倍半萜二聚体。其中11个化合物与临床一线抗肝癌药物活性相当，且南牡蒿素G7安全性更优，并通过WB、CETSA、ITC和SPR试验验证了其作用于PDGFRA靶点、影响AKT/STAT信号通路从而发挥抗肝癌活性，为新型抗肝癌药物研发提供了结构多样的候选分子和重要的药理学基础。

主持国家自然科学基金青年基金、中国科学院特别研究助理、云南省博士后定向培养、中科院昆明植物研究所自主开放课题等项目。以第一作者（排名第一）在Signal Transduction and Targeted Therapy (中科院一区TOP, IF = 39.1)、Chinese Chemical Letters (一区, IF = 9.1)、Journal of Agricultural and Food Chemistry (一区, IF = 6.1)、Industrial Crops and Products (一区, IF = 5.9)、Organic Chemistry Frontiers (一区, IF = 5.4)、Bioorganic Chemistry (3篇, 一区, IF = 5.1)、Phytochemistry、Chinese Journal of Chemistry、Organic & Biomolecular Chemistry等领域权威期刊发表SCI学术论文16篇，参与发表论文20余篇。

联系电话：15198737656，[email protected]

二、代表性成果（可含承担项目、发表论文、论著、获奖等）

承担项目（主持）

1. 国家自然科学基金委员会青年科学基金项目，82104040，南牡蒿和白莲蒿中新颖抗肝癌活性倍半萜二聚体的快速发现和作用机制研究，2022.01至2024.12，30万元，主持。

2. 中国科学院特别研究助理资助项目，E12D9211Q1，南牡蒿和白莲蒿中新颖倍半萜二聚体的抗肝癌活性成分发现，结构优化和作用机制研究，2020.09至2022.09，60万元，主持。

3. 云南省博士后定向培养资助项目，E131821261，南牡蒿和白莲蒿中抗肝癌活性成分发现、结构优化和作用机制研究，2020.09至2022.09，16万元，主持。

4. 中国科学院昆明植物研究所自主开放课题，植物化学与西部植物资源持续利用国家重点实验室专项经费，2021.01至2023.12，15万元，主持

发表论文（第一作者排名第一）

1. Xiao-Feng He, Yun-Bao Ma, Tian-Ze Li, Ji-Jun Chen. Highly oxygenated guaiane-type sesquiterpene lactones from Artemisia sacrorum and their antihepatoma activity. Phytochemistry, 2024, 217, 113930. (中科院二区, IF = 3.8)

2. Xiao-Feng He, Wen-Jjing Ma, Jing Hu, Tian-Ze Li, Chang-An Geng, Yun-Bao Ma, Meng-Fei Wang, Ke-Xin Yang, Xue-Mei Zhang, Ji-Jun Chen. Diverse structures and antihepatoma effect of sesquiterpenoid dimers from Artemisia eriopoda by AKT/STAT signaling pathway. Signal Transduction and Targeted Therapy, 2023, 8, 64. (中科院一区, IF = 39.3)

3. Xiao-Feng He, Qi-Hao Li, Tian-Ze Li, Yun-Bao Ma, Wei Dong, Ke-Xin Yang, Chang-An Geng, Hao-Wei Zhang, Yuan Wang, Ji-Jun Chen. Artemeriopolides A‒D, two types of sesquiterpenoid dimers with rare carbon skeletons from Artemisia eriopoda and their antihepatoma cytotoxicity. Organic Chemistry Frontiers, 2023. 10, 2635–2641. (中科院一区, IF = 5.4)

4. Xiao-Feng He, Meng-Fei Wang, Tian-Ze Li, Yun-Bao Ma, Ji-Jun Chen. Artemannuols A–C, novel sesquiterpenoid-flavonol hybrids with antihepatoma activity from Artemisia annua. Organic & Biomolecular Chemistry, 2023, 21, 5451–5456. (中科院三区, IF = 3.2)

5. Xiao-Feng He, Meng-Fei Wang, Yun-Bao Ma, Tian-Ze Li, Ji-Jun Chen. Artemeriosides A–F, the first examples of natural sesquiterpenoids substituted by a 6′-O-crontonyl β-glucopyranoside from Artemisia annua. Fitoterapia, 2023, 169, 105619. (中科院三区, IF = 3.4)

6. Xiao-Feng He, Sheng-Li Wu, Ji-Jun Chen, Jing Hu, Xiao-Yan Huang, Tian-Ze Li, Xue-Mei Zhang, Yuan-Qiang Guo, Chang-An Geng. New diarylheptanoid dimers as GLP-1 secretagogues and multiple-enzyme inhibitors from Alpinia katsumadai. Bioorganic Chemistry, 2022, 120, 10563. (中科院一区, IF = 5.1)

7. Xiao-Feng He, Ji-Jun Chen, Tian-Ze Li, Jing Hu, Xue-Mei Zhang; Chang-An Geng. Diarylheptanoid-chalcone hybrids with PTP1B and α-glucosidase dual inhibition from Alpinia katsumadai. Bioorganic Chemistry, 2021, 108, 104683. (中科院一区, IF = 5.1)

8. Xiao-Feng He, Ji-Jun Chen, Xiao-Yan Huang, Jing Hu, Xu-Ke Zhang, Yuan-Qiang Guo, Xue-Mei Zhang, Chang-An Geng. The antidiabetic potency of Amomum tsao-ko and its active flavanols, as PTP1B selective and α-glucosidase dual inhibitors. Industrial Crops and Products, 2021, 160, 112908. (中科院一区, IF = 5.9)

9. Xiao-Feng He, Ji-Jun Chen, Tian-Ze Li, Jing Hu, Xiao-Yan Huang, Xue-Mei Zhang, Yuan-Qiang Guo, Chang-An Geng. Diarylheptanoid-flavanone hybrids as multiple-target antidiabetic agents from Alpinia katsumadai. Chinese Journal of Chemistry, 2021, 39, 3051−3063. (中科院二区, IF = 5.4)

10. Xiao-Feng He, Ji-Jun Chen, Tian-Ze Li, Jing Hu, Xu-Ke Zhang, Yuan-Qiang Guo, Xue-Mei Zhang, Chang-An Geng. Tsaokols A and B, unusual flavanol-monoterpenoid hybrids as α-glucosidase inhibitors from Amomum tsao-ko. Chinese Chemical Letters, 2020, 32, 1202–1205. (中科院一区, IF = 9.1)

11. Xiao-Feng He, Ji-Jun Chen, Tian-Ze Li, Xu-Ke Zhang, Yuan-Qiang Guo, Xue-Mei Zhang, Jing Hu, Chang-An Geng. Nineteen new flavanol-fatty alcohol hybrids with α-glucosidase and PTP1B dual inhibition, one unusual type of antidiabetic constituents from Amomum tsao-ko. Journal of Agricultural and Food Chemistry, 2020, 68, 11434−11448. (中科院一区, IF = 6.1)

12. Xiao-Feng He, Xu-Ke Zhang, Chang-An Geng, Jing Hu, Xue-Mei Zhang, Yuan-Qiang Guo, Ji-Jun Chen. Tsaokopyranols A–M, 2,6-epoxydiarylheptanoids from Amomum tsao-ko and their α-glucosidase inhibitory activity. Bioorganic Chemistry, 2020, 96, 103638. (中科院一区, IF = 5.1)

13. Xiao-Feng He, Hui-Mei Wang, Chang-An Geng, Jing Hu, Xue-Mei Zhang, Yuan-Qiang Guo, Ji-Jun Chen. Amomutsaokols A–K, diarylheptanoids from Amomum tsao-ko and their α-glucosidase inhibitory activity. Phytochemistry, 2020, 177, 112418. (中科院二区, IF = 3.8)

14. Xiao-Feng He, Chang-An Geng, Xiao-Yan Huang, Yun-Bao Ma, Xue-Mei Zhang, Ji-Jun Chen. Chemical constituents from Mentha haplocalyx Briq. (Mentha canadensis L.) and their α-glucosidase inhibitory activities. Natural Products and Bioprospecting, 2019, 9, 223–229.

15. Xiao-Feng He, Xiao-Dong Hou, Xia Ren, Kai Guo, Xiu-Zhuang Li, Zhi-Qiang Yan, Yong-Mei Du, Zhong-Feng Zhang, Bo Qin. Two new cembranic diterpenoids from the flowers of Nicotiana tabacum L. Phytochemistry Letters, 2016, 15, 238–244. (中科院四区, IF = 1.7)

16. Xiao-Feng He, Zi-Wei He, Xiao-Jie Jin, Xiao-Yan Pang, Jing-Guo Gao, Xiao-Jun Yao, Ying Zhu. Caryolane-type sesquiterpenes from Cirsium souliei. Phytochemistry Letters, 2014, 10, 80–85. (中科院四区, IF = 1.7)